Peppi Koivunen Selected Research

Enzymes

12/2020	2-Oxoglutarate-dependent dioxygenases in cancer.
1/2019	Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice.
12/2018	Hypoxia-Inducible Factor Prolyl 4-Hydroxylases and Metabolism.
4/2018	The TET enzymes.
1/2018	Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases.
12/2016	Hypoxia-inducible factor prolyl 4-hydroxylase inhibition in cardiometabolic diseases.
2/2016	Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.
3/2013	(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.
2/2012	Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
3/2004	Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.

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Peppi Koivunen Research Topics

Disease

46	Hypoxia (Hypoxemia) 03/2024 - 08/2003
18	Neoplasms (Cancer) 03/2024 - 02/2007
7	Inflammation (Inflammations) 01/2022 - 01/2016
7	Insulin Resistance 01/2022 - 10/2014
4	Ischemia 01/2022 - 04/2010
4	Breast Neoplasms (Breast Cancer) 01/2019 - 01/2013
4	Carcinogenesis 01/2018 - 01/2013
2	Atherosclerosis 02/2024 - 04/2016
2	Neuroinflammatory Diseases 07/2022 - 01/2022
2	Weight Gain 01/2022 - 04/2016
2	Atherosclerotic Plaque (Atheroma) 01/2021 - 04/2016
2	Birth Weight (Birth Weights) 03/2020 - 11/2018
2	Fibrosis (Cirrhosis) 10/2017 - 01/2016
2	Lung Neoplasms (Lung Cancer) 08/2017 - 10/2014
2	Polycythemia (Erythrocytosis) 01/2017 - 01/2016
2	Anemia 12/2016 - 04/2016
2	Obesity 04/2016 - 10/2014
2	Neuroblastoma 02/2016 - 10/2007
1	Adenocarcinoma 03/2024
1	Pancreatic Neoplasms (Pancreatic Cancer) 03/2024
1	Myocardial Infarction 12/2023
1	Iron Deficiencies 10/2023
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2023
1	Alzheimer Disease (Alzheimer's Disease) 01/2023
1	Glioma (Gliomas) 01/2023
1	Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced) 01/2022
1	Gestational Weight Gain 01/2022
1	Body Weight (Weight, Body) 01/2022
1	Hyperglycemia 01/2022
1	Hypertrophy 01/2022
1	Gestational Diabetes (Gestational Diabetes Mellitus) 01/2022
1	Stroke (Strokes) 01/2022
1	Dyslipidemias (Dyslipidemia) 01/2022
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2021
1	Wounds and Injuries (Trauma) 01/2020
1	Non-alcoholic Fatty Liver Disease 01/2020
1	Alcoholic Fatty Liver 01/2019
1	Fatty Liver 01/2019
1	Fetal Weight 11/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2017
1	Triple Negative Breast Neoplasms 06/2016

Drug/Important Bio-Agent (IBA)

23	Oxygen (Dioxygen)IBA 01/2022 - 08/2003
14	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 11/2023 - 10/2007
10	EnzymesIBA 12/2020 - 03/2004
10	Transcription Factors (Transcription Factor)IBA 01/2019 - 03/2004
9	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 04/2013
8	Proteins (Proteins, Gene)FDA Link 07/2022 - 01/2005
5	Ketoglutaric Acids (Ketoglutaric Acid)IBA 01/2023 - 12/2004
5	CollagenIBA 01/2021 - 01/2005
5	Mixed Function Oxygenases (Monooxygenases)IBA 01/2017 - 08/2005
4	Histones (Histone)IBA 03/2024 - 01/2018
4	Histone DemethylasesIBA 03/2024 - 01/2018
4	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2023 - 02/2012
4	IsoenzymesIBA 01/2022 - 04/2013
4	Succinate Dehydrogenase (Fumarate Reductase)IBA 12/2020 - 02/2007
3	Hemoglobins (Hemoglobin)IBA 01/2022 - 01/2021
3	Messenger RNA (mRNA)IBA 01/2022 - 01/2013
3	CholesterolIBA 01/2022 - 04/2016
3	Fumarate Hydratase (Fumarase)IBA 12/2020 - 02/2012
3	Erythropoietin FDA Link 01/2017 - 01/2016
3	IronIBA 12/2016 - 04/2013
3	Succinic Acid (Succinate)IBA 02/2016 - 02/2007
3	FumaratesIBA 02/2016 - 02/2007
3	Peptides (Polypeptides)IBA 09/2006 - 12/2004
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2024 - 01/2019
2	Triglycerides (Triacylglycerol)IBA 02/2024 - 01/2022
2	Leucine (L-Leucine)FDA Link 10/2023 - 01/2022
2	DioxygenasesIBA 01/2023 - 12/2020
2	Small Interfering RNA (siRNA)IBA 01/2022 - 10/2007
2	alpha-hydroxyglutarateIBA 01/2019 - 03/2013
2	LipidsIBA 04/2016 - 01/2016
2	Estrogens (Estrogen)FDA Link 01/2013 - 05/2012
2	disodium salt olean-11,13(18)-diene-3,30-diol dihemiphthalateIBA 10/2007 - 09/2006
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 03/2024
1	Histone MethyltransferasesIBA 03/2024
1	Biomarkers (Surrogate Marker)IBA 12/2023
1	Mechanistic Target of Rapamycin Complex 1IBA 10/2023
1	phytanoyl-coenzyme A (phytanoyl CoA)IBA 01/2023
1	Lysine (L-Lysine)FDA Link 01/2023
1	Protein AggregatesIBA 07/2022
1	Amyloid (Amyloid Fibrils)IBA 07/2022
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2022
1	FructoseIBA 01/2020
1	Methionine (L-Methionine)FDA Link 01/2020
1	Choline (Choline Chloride)IBA 01/2020
1	AntioxidantsIBA 01/2019
1	Ethanol (Ethyl Alcohol)IBA 01/2019
1	Lipoproteins (Lipoprotein)IBA 01/2019
1	Ubiquitin-Specific ProteasesIBA 01/2018
1	Collagen Type I (Type I Collagen)IBA 10/2017
1	Cysteine (L-Cysteine)FDA Link 06/2016
1	Glutamic Acid (Glutamate)FDA Link 06/2016
1	LDL Lipoproteins (beta Lipoproteins)IBA 04/2016
1	CopperIBA 04/2016
1	LDL Receptors (LDL Receptor)IBA 04/2016
1	AutoantibodiesIBA 04/2016
1	oxidized low density lipoproteinIBA 04/2016

Therapy/Procedure

7	Therapeutics 03/2024 - 10/2014
1	Drug Therapy (Chemotherapy) 03/2024
1	Cardiopulmonary Bypass (Heart-Lung Bypass) 08/2017